CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family Carnitinyl-CoA dehydratase

Enzyme Information

4.2.1.150
Short-chain-enoyl-CoA hydratase.
based on mapping to UniProt P52046
A short-chain (3S)-3-hydroxyacyl-CoA = a short-chain trans-2-enoyl-CoA + H(2)O.
-!- The enzyme from the bacterium Clostridium acetobutylicum is part of the central fermentation pathway and plays a key role in the production of both acids and solvents. -!- It is specific for short, C(4)-C(6), chain length substrates and exhibits an extremely high turnover number for crotonyl-CoA. -!- Cf. EC 4.2.1.17 and EC 4.2.1.74.

UniProtKB Entries (1)

P52046
CRT_CLOAB
Clostridium acetobutylicum ATCC 824
Short-chain-enoyl-CoA hydratase

PDB Structure

PDB 5Z7R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights into substrate specificity of crotonase from the n-butanol producing bacterium Clostridium acetobutylicum.
Kim, E.J., Kim, Y.J., Kim, K.J.
Biochem. Biophys. Res. Commun.