CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Mitogen-activated protein kinase kinase kinase 12

Enzyme Information

2.7.11.25
Mitogen-activated protein kinase kinase kinase.
based on mapping to UniProt Q12852
ATP + a protein = ADP + a phosphoprotein.
-!- This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation. -!- Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. -!- While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway. -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q12852
M3K12_HUMAN
Homo sapiens
Mitogen-activated protein kinase kinase kinase 12

PDB Structure

PDB 5VO2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.
Patel, S., Meilandt, W.J., Erickson, R.I., Chen, J., Deshmukh, G., Estrada, A.A., Fuji, R.N., Gibbons, P., Gustafson, A., Harris, S.F., Imperio, J., Liu, W., Liu, X., Liu, Y., Lyssikatos, J.P., Ma, C., Yin, J., Lewcock, J.W., Siu, M.
J. Med. Chem.