CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Vascular endothelial growth factor receptor 2

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P35968
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P35968
VGFR2_HUMAN
Homo sapiens
Vascular endothelial growth factor receptor 2

PDB Structure

PDB 5OYJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Characterization of a drug-targetable allosteric site regulating vascular endothelial growth factor signaling.
Thieltges, K.M., Avramovic, D., Piscitelli, C.L., Markovic-Mueller, S., Binz, H.K., Ballmer-Hofer, K.
Angiogenesis