CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family Furin 2, isoform B

Enzyme Information

3.4.21.75
Furin.
based on mapping to UniProt P09958
Release of mature proteins from their proproteins by cleavage of -Arg- Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
-!- Activated by calcium. -!- Belongs to peptidase family S8.

UniProtKB Entries (1)

P09958
FURIN_HUMAN
Homo sapiens
Furin

PDB Structure

PDB 5JMO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
Dahms, S.O., Creemers, J.W., Schaub, Y., Bourenkov, G.P., Zogg, T., Brandstetter, H., Than, M.E.
Sci Rep