CATH Classification

Domain Context

CATH Clusters

Superfamily Endonuclease/exonuclease/phosphatase
Functional Family Tyrosyl-DNA phosphodiesterase 2

Enzyme Information

3.1.4.-
Phosphoric diester hydrolases.
based on mapping to UniProt O95551

UniProtKB Entries (1)

O95551
TYDP2_HUMAN
Homo sapiens
Tyrosyl-DNA phosphodiesterase 2

PDB Structure

PDB 5J3S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Hornyak, P., Askwith, T., Walker, S., Komulainen, E., Paradowski, M., Pennicott, L.E., Bartlett, E.J., Brissett, N.C., Raoof, A., Watson, M., Jordan, A.M., Ogilvie, D.J., Ward, S.E., Atack, J.R., Pearl, L.H., Caldecott, K.W., Oliver, A.W.
Biochem.J.