CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Matrix metalloproteinase-14 preproprotein

Enzyme Information

3.4.24.80
Membrane-type matrix metalloproteinase-1.
based on mapping to UniProt P50281
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe- 342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
-!- Believed to play an important role in the activation of progelatinase A at cell surfaces. -!- Belongs to peptidase family M10.

UniProtKB Entries (1)

P50281
MMP14_HUMAN
Homo sapiens
Matrix metalloproteinase-14

PDB Structure

PDB 5H0U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Solvent water interactions within the active site of the membrane type I matrix metalloproteinase.
Decaneto, E., Vasilevskaya, T., Kutin, Y., Ogata, H., Grossman, M., Sagi, I., Havenith, M., Lubitz, W., Thiel, W., Cox, N.
Phys Chem Chem Phys