CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine-protein kinase Nek7

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q8TDX7
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (2)

Q8K1R7
NEK9_MOUSE
Mus musculus
Serine/threonine-protein kinase Nek9
Q8TDX7
NEK7_HUMAN
Homo sapiens
Serine/threonine-protein kinase Nek7

PDB Structure

PDB 5DE2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.
Haq, T., Richards, M.W., Burgess, S.G., Gallego, P., Yeoh, S., O'Regan, L., Reverter, D., Roig, J., Fry, A.M., Bayliss, R.
Nat Commun