CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Adenosylhomocysteinase

Enzyme Information

3.3.1.1
Adenosylhomocysteinase.
based on mapping to UniProt P50247
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

P50247
SAHH_MOUSE
Mus musculus
Adenosylhomocysteinase

PDB Structure

PDB 5AXD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of mouse SAHH complexed with ribavirin
Kusakabe, Y., Ishihara, M., Tanaka, N.
To Be Published