CATH Classification

Domain Context

CATH Clusters

Superfamily 2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily
Functional Family Tetratricopeptide repeat protein 25

Enzyme Information

3.1.4.37
2',3'-cyclic-nucleotide 3'-phosphodiesterase.
based on mapping to UniProt P16330
Nucleoside 2',3'-cyclic phosphate + H(2)O = nucleoside 2'-phosphate.
-!- The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives. -!- An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyzes the corresponding 3',5'-cyclic phosphates, more slowly. -!- This latter enzyme has been called cyclic-CMP phosphodiesterase.

UniProtKB Entries (1)

P16330
CN37_MOUSE
Mus musculus
2',3'-cyclic-nucleotide 3'-phosphodiesterase

PDB Structure

PDB 5AE0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase.
Raasakka, A., Myllykoski, M., Laulumaa, S., Lehtimaki, M., Hartlein, M., Moulin, M., Kursula, I., Kursula, P.
Sci Rep