CATH Classification

Domain Context

CATH Clusters

Superfamily B-lactam Antibiotic, Isopenicillin N Synthase; Chain
Functional Family Feruloyl CoA ortho-hydroxylase 1

Enzyme Information

1.14.11.61
Feruloyl-CoA 6-hydroxylase.
based on mapping to UniProt Q9LHN8
Trans-feruloyl-CoA + 2-oxoglutarate + O(2) = trans-6-hydroxy-feruloyl-CoA + succinate + CO(2).
-!- Requires iron(II) and ascorbate. -!- The product spontaneously undergoes trans-cis isomerization and lactonization to form scopoletin, liberating CoA in the process. -!- The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-4-coumaroyl-CoA. -!- Cf. EC 1.14.11.62.

UniProtKB Entries (1)

Q9LHN8
F6H1_ARATH
Arabidopsis thaliana
Feruloyl CoA ortho-hydroxylase 1

PDB Structure

PDB 4XAE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insights into Substrate Specificity of Feruloyl-CoA 6'-Hydroxylase from Arabidopsis thaliana.
Sun, X., Zhou, D., Kandavelu, P., Zhang, H., Yuan, Q., Wang, B.C., Rose, J., Yan, Y.
Sci Rep