CATH Classification

Domain Context

CATH Clusters

Superfamily Glycogen Phosphorylase B;
Functional Family

Enzyme Information

2.4.1.70
Poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase.
based on mapping to UniProt A0A0D6HUA0
n UDP-N-acetyl-alpha-D-glucosamine + 4-O-(D-ribitylphospho)(n)-di((2R)-1- glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D- glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-(2-N- acetyl-alpha-D-glucosaminyl-D-ribitylphospho)(n)-di((2R)-1- glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D- glucosaminyl-diphospho-ditrans,octacis-undecaprenol.
-!- Involved in the biosynthesis of poly(ribitol phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus. -!- This enzyme adds an N-acetyl-alpha-D-glucosamine to the hydroxyl group at the 2 position of the ribitol phosphate units. -!- Cf. EC 2.4.1.355.

UniProtKB Entries (1)

A0A0D6HUA0
A0A0D6HUA0_STAAU
Staphylococcus aureus
Glycosyl transferase family 1

PDB Structure

PDB 4WAD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Enzymatic Analysis of TarM Glycosyltransferase from Staphylococcus aureus Reveals an Oligomeric Protein Specific for the Glycosylation of Wall Teichoic Acid.
Koc, C., Gerlach, D., Beck, S., Peschel, A., Xia, G., Stehle, T.
J.Biol.Chem.