CATH Classification

Domain Context

CATH Clusters

Superfamily 2.20.28.10
Functional Family Minichromosome maintenance protein MCM

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q9UXG1
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (2)

Q9UXG1
MCM_SACS2
Saccharolobus solfataricus P2
Minichromosome maintenance protein MCM
Q8U3I4
Q8U3I4_PYRFU
Pyrococcus furiosus DSM 3638
Cell division control protein 21

PDB Structure

PDB 4R7Y
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Analysis of the crystal structure of an active MCM hexamer.
Miller, J.M., Arachea, B.T., Epling, L.B., Enemark, E.J.
Elife