CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P52333
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P52333
JAK3_HUMAN
Homo sapiens
Tyrosine-protein kinase JAK3

PDB Structure

PDB 4QPS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol.
Goedken, E.R., Argiriadi, M.A., Banach, D.L., Fiamengo, B.A., Foley, S.E., Frank, K.E., George, J.S., Harris, C.M., Hobson, A.D., Ihle, D.C., Marcotte, D., Merta, P.J., Michalak, M.E., Murdock, S.E., Tomlinson, M.J., Voss, J.W.
J.Biol.Chem.