CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Mast/stem cell growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P10721
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P10721
KIT_HUMAN
Homo sapiens
Mast/stem cell growth factor receptor Kit

PDB Structure

PDB 4PGZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Reshetnyak, A.V., Opatowsky, Y., Boggon, T.J., Folta-Stogniew, E., Tome, F., Lax, I., Schlessinger, J.
Mol.Cell