CATH Classification

Domain Context

CATH Clusters

Superfamily Chondroitin AC/alginate lyase
Functional Family Heparin-sulfate lyase

Enzyme Information

4.2.2.8
Heparin-sulfate lyase.
based on mapping to UniProt Q59289
Elimination of sulfate, appears to act on linkages between N-acetyl-D- glucosamine and uronate. Product is an unsaturated sugar.
-!- Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.

UniProtKB Entries (1)

Q59289
HEPC_PEDHD
Pedobacter heparinus DSM 2366
Heparin-sulfate lyase

PDB Structure

PDB 4MMH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Pedobacter heparinus Heparin Lyase Hep III with the Active Site in a Deep Cleft
Hashimoto, W., Maruyama, Y., Nakamichi, Y., Mikami, B., Murata, K.
Biochemistry