CATH Classification

Domain Context

CATH Clusters

Superfamily C-terminal domain of ProRS
Functional Family Bifunctional glutamate/proline--tRNA ligase

Enzyme Information

6.1.1.15
Proline--tRNA ligase.
based on mapping to UniProt P07814
ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
6.1.1.17
Glutamate--tRNA ligase.
based on mapping to UniProt P07814
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

UniProtKB Entries (1)

P07814
SYEP_HUMAN
Homo sapiens
Bifunctional glutamate/proline--tRNA ligase

PDB Structure

PDB 4K88
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.
Son, J., Lee, E.H., Park, M., Kim, J.H., Kim, J., Kim, S., Jeon, Y.H., Hwang, K.Y.
Acta Crystallogr.,Sect.D