CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family |
Enzyme Information
| 1.14.13.240 |
2-polyprenylphenol 6-hydroxylase.
based on mapping to UniProt P25535
2-(all-trans-polyprenyl)phenol + NADPH + O(2) = 3-(all-trans- polyprenyl)benzene-1,2-diol + NADP(+) + H(2)O.
-!- The enzyme from the bacterium Escherichia coli (UbiI) catalyzes the first hydroxylation during the aerobic biosynthesis of ubiquinone. -!- The enzyme from the bacterium Neisseria meningitidis (UbiM) can also catalyze the two additional hydroxylations that occur in the pathway (cf. EC 1.14.99.60).
|
UniProtKB Entries (1)
| P25535 |
UBII_ECOLI
Escherichia coli K-12
2-octaprenylphenol hydroxylase
|
PDB Structure
| PDB | 4K22 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
ubiI, a New Gene in Escherichia coli Coenzyme Q Biosynthesis, Is Involved in Aerobic C5-hydroxylation.
J.Biol.Chem.
|