CATH Classification

Domain Context

CATH Clusters

Superfamily Ureohydrolase domain
Functional Family Arginase

Enzyme Information

3.5.3.1
Arginase.
based on mapping to UniProt P78540
L-arginine + H(2)O = L-ornithine + urea.
-!- Also hydrolyzes alpha-N-substituted L-arginines and canavanine.

UniProtKB Entries (1)

P78540
ARGI2_HUMAN
Homo sapiens
Arginase-2, mitochondrial

PDB Structure

PDB 4IXV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
Golebiowski, A., Whitehouse, D., Beckett, R.P., Van Zandt, M., Ji, M.K., Ryder, T.R., Jagdmann, E., Andreoli, M., Lee, Y., Sheeler, R., Conway, B., Olczak, J., Mazur, M., Czestkowski, W., Piotrowska, W., Cousido-Siah, A., Ruiz, F.X., Mitschler, A., Podjarny, A., Schroeter, H.
Bioorg.Med.Chem.Lett.