CATH Classification

Domain Context

CATH Clusters

Superfamily tRNA(m1g37)methyltransferase, domain 2
Functional Family

Enzyme Information

2.1.1.228
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt Q2GIL5
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

Q2GIL5
TRMD_ANAPZ
Anaplasma phagocytophilum str. HZ
TRNA (guanine-N(1)-)-methyltransferase

PDB Structure

PDB 4IG6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of a tRNA (guanine-N1)-methyltransferase from Anaplasma phagocytophilum bound to S-adenosylhomocysteine
Edwards, T.E., Clifton, M.C., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
TO BE PUBLISHED