CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Interferon-induced with helicase C domain 1

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt Q9BYX4
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q9BYX4
IFIH1_HUMAN
Homo sapiens
Interferon-induced helicase C domain-containing protein 1

PDB Structure

PDB 4GL2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5.
Wu, B., Peisley, A., Richards, C., Yao, H., Zeng, X., Lin, C., Chu, F., Walz, T., Hur, S.
Cell(Cambridge,Mass.)