CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Dual specificity protein kinase TTK

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt P33981
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P33981
TTK_HUMAN
Homo sapiens
Dual specificity protein kinase TTK

PDB Structure

PDB 4C4F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3, 2-C]Pyridine Inhibitors of the Mitotic Kinase Monopolar Spindle 1 (Mps1).
Naud, S., Westwood, I.M., Faisal, A., Sheldrake, P.W., Bavetsias, V., Atrash, B., Cheung, K.J., Liu, M., Hayes, A., Schmitt, J., Wood, A., Choi, V., Boxall, K., Mak, G., Gurden, M., Valenti, M., De-Haven-Brandon, A., Henley, A., Baker, R., Mcandrew, C., Matijssen, B., Burke, R., Hoelder, S., Eccles, S.A., Raynaud, F.I., Linardopoulos, S., Van Montfort, R.L.M., Blagg, J.
J.Med.Chem.