CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Vascular endothelial growth factor receptor 3

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P35916
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P35916
VGFR3_HUMAN
Homo sapiens
Vascular endothelial growth factor receptor 3

PDB Structure

PDB 4BSJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Mechanistic Insights Into Vegfr-3 Ligand Binding and Activation
Leppanen, V.-M., Tvorogov, D., Kisko, K., Prota, A.E., Jeltsch, M., Anisimov, A., Markovic-Mueller, S., Stuttfeld, E., Goldie, K.N., Ballmer-Hofer, K., Alitalo, K.
Proc.Natl.Acad.Sci.USA