CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Putative cyclin-dependent kinase-like 5

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt O76039
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

O76039
CDKL5_HUMAN
Homo sapiens
Cyclin-dependent kinase-like 5

PDB Structure

PDB 4BGQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Human Cdkl5 Kinase Domain
Canning, P., Krojer, T., Goubin, S., Mahajan, P., Vollmar, M., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
To be Published