CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family U5 small nuclear ribonucleoprotein helicase

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt P32639
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

P33334
PRP8_YEAST
Saccharomyces cerevisiae S288C
Pre-mRNA-splicing factor 8

PDB Structure

PDB 4BGD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of Brr2-Prp8 Interactions and Implications for U5 Snrnp Biogenesis and the Spliceosome Active Site
Nguyen, T.H.D., Li, J., Galej, W.P., Oshikane, H., Newman, A.J., Nagai, K.
Structure