CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Putative dual specificity tyrosine-phosphorylation-regulated kinase 2

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt Q92630
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q92630
DYRK2_HUMAN
Homo sapiens
Dual specificity tyrosine-phosphorylation-regulated kinase 2

PDB Structure

PDB 4AZF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Selectivity, Co-Crystal Structures and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.
Tahtouh, T., Elkins, J.M., Filippakopoulos, P., Soundararajan, M., Burgy, G., Durieu, E., Cochet, C., Schmid, R.S., Lo, D.C., Delhommel, F., Oberholzer, A., Laurence, P., Carreaux, F., Bazureau, J.P., Knapp, S., Meijer, L.
J.Med.Chem.