CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Replicative DNA helicase

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt O25916
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

O25916
DNAB_HELPY
Helicobacter pylori 26695
Replicative DNA helicase

PDB Structure

PDB 4A1F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Architecture of a Dodecameric Bacterial Replicative Helicase.
Stelter, M., Gutsche, I., Kapp, U., Bazin, A., Bajic, G., Goret, G., Jamin, M., Timmins, J., Terradot, L.
Structure