CATH Classification

Domain Context

CATH Clusters

Superfamily [2Fe-2S]-binding domain
Functional Family Aldehyde oxidase 1

Enzyme Information

1.17.3.-
With oxygen as acceptor.
based on mapping to UniProt G3X982
1.2.3.1
Aldehyde oxidase.
based on mapping to UniProt G3X982
An aldehyde + H(2)O + O(2) = a carboxylate + H(2)O(2).
-!- The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides. -!- The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11). -!- Formerly EC 1.2.3.11.

UniProtKB Entries (1)

G3X982
AOXC_MOUSE
Mus musculus
Aldehyde oxidase 3

PDB Structure

PDB 3ZYV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The First Mammalian Aldehyde Oxidase Crystal Structure: Insights Into Substrate Specificity.
Coelho, C., Mahro, M., Trincao, J., Carvalho, A.T.P., Ramos, M.J., Terao, M., Garattini, E., Leimkuhler, S., Romao, M.J.
J.Biol.Chem.