CATH Classification

Domain Context

CATH Clusters

Superfamily 2.30.30.50
Functional Family

Enzyme Information

4.2.1.84
Nitrile hydratase.
based on mapping to UniProt P13449
An aliphatic amide = a nitrile + H(2)O.
-!- Acts on short-chain aliphatic nitriles, converting them into the corresponding acid amides. -!- Does not act on these amides or on aromatic nitriles (cf. EC 3.5.5.1).

UniProtKB Entries (1)

P13449
NHAB_RHOER
Rhodococcus erythropolis
Nitrile hydratase subunit beta

PDB Structure

PDB 3X25
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Time-Resolved Crystallography of the Reaction Intermediate of Nitrile Hydratase: Revealing a Role for the Cysteinesulfenic Acid Ligand as a Catalytic Nucleophile.
Yamanaka, Y., Kato, Y., Hashimoto, K., Iida, K., Nagasawa, K., Nakayama, H., Dohmae, N., Noguchi, K., Noguchi, T., Yohda, M., Odaka, M.
Angew.Chem.Int.Ed.Engl.