CATH Classification

Domain Context

CATH Clusters

Superfamily N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family Ketol-acid reductoisomerase (NADP(+))

Enzyme Information

1.1.1.86
Ketol-acid reductoisomerase (NADP(+)).
based on mapping to UniProt P05793
(1) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NADPH. (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2- ethyl-3-oxobutanoate + NADPH.
-!- The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382 and EC 1.1.1.383). -!- Formerly EC 1.1.1.89.

UniProtKB Entries (1)

P05793
ILVC_ECOLI
Escherichia coli K-12
Ketol-acid reductoisomerase (NADP(+))

PDB Structure

PDB 3ULK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle
Wong, S.H., Lonhienne, T.G.A., Winzor, D.J., Schenk, G., Guddat, L.W.
J.Mol.Biol.