CATH Classification

Domain Context

CATH Clusters

Superfamily Uracil-DNA glycosylase-like domain
Functional Family G/T mismatch-specific thymine DNA glycosylase

Enzyme Information

3.2.2.29
Thymine-DNA glycosylase.
based on mapping to UniProt Q13569
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.
-!- Thymine-DNA glycosylase is part of the DNA-repair machinery. -!- Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. -!- The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T.

UniProtKB Entries (1)

Q13569
TDG_HUMAN
Homo sapiens
G/T mismatch-specific thymine DNA glycosylase

PDB Structure

PDB 3UFJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA.
Maiti, A., Noon, M.S., Mackerell, A.D., Pozharski, E., Drohat, A.C.
Proc.Natl.Acad.Sci.USA