CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Vascular endothelial growth factor receptor 3

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P35968
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P35968
VGFR2_HUMAN
Homo sapiens
Vascular endothelial growth factor receptor 2

PDB Structure

PDB 3S37
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structural Basis for the Function of Two Anti-VEGF Receptor 2 Antibodies.
Franklin, M.C., Navarro, E.C., Wang, Y., Patel, S., Singh, P., Zhang, Y., Persaud, K., Bari, A., Griffith, H., Shen, L., Balderes, P., Kussie, P.
Structure