CATH Classification

Domain Context

CATH Clusters

Superfamily N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family 3-hydroxybutyryl-CoA dehydrogenase FadB2

Enzyme Information

1.1.1.35
3-hydroxyacyl-CoA dehydrogenase.
based on mapping to UniProt Q16836
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
-!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).

UniProtKB Entries (1)

Q16836
HCDH_HUMAN
Homo sapiens
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

PDB Structure

PDB 3RQS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Northeast Structural Genomics Consortium Target HR487
Kuzin, A., Su, M., Seetharaman, J., Patel, P., Xiao, R., Ciccosanti, C., Shastry, R., Everett, J.K., Nair, R., Acton, T.B., Rost, B., Montelione, G.T., Tong, L., Hunt, J.F.
To be published