CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Receptor protein serine/threonine kinase

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt P37023
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P37023
ACVL1_HUMAN
Homo sapiens
Serine/threonine-protein kinase receptor R3

PDB Structure

PDB 3MY0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.
Kerr, G., Sheldon, H., Chaikuad, A., Alfano, I., von Delft, F., Bullock, A.N., Harris, A.L.
Angiogenesis