CATH Classification

Domain Context

CATH Clusters

Superfamily Copper amine oxidase, catalytic domain
Functional Family Amine oxidase

Enzyme Information

1.4.3.22
Diamine oxidase.
based on mapping to UniProt P19801
Histamine + H(2)O + O(2) = (imidazol-4-yl)acetaldehyde + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 but unlike EC 1.4.3.4, they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

P19801
AOC1_HUMAN
Homo sapiens
Amiloride-sensitive amine oxidase [copper-containing]

PDB Structure

PDB 3MPH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Correlation of active site metal content in human diamine oxidase with trihydroxyphenylalanine quinone cofactor biogenesis
McGrath, A.P., Caradoc-Davies, T., Collyer, C.A., Guss, J.M.
Biochemistry