CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.450.40
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt O76074
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

O76074
PDE5A_HUMAN
Homo sapiens
CGMP-specific 3',5'-cyclic phosphodiesterase

PDB Structure

PDB 3MF0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain.
Wang, H., Robinson, H., Ke, H.
J.Biol.Chem.