CATH Classification

Domain Context

CATH Clusters

Superfamily Glucose Oxidase, domain 2
Functional Family

Enzyme Information

1.1.3.17
Choline oxidase.
based on mapping to UniProt Q7X2H8
Choline + 2 O(2) + H(2)O = betaine + 2 H(2)O(2).
-!- In many bacteria, plants and animals, the osmoprotectant betaine is synthesized using different enzymes to catalyze the conversion of (1) choline into betaine aldehyde and (2) betaine aldehyde into betaine. -!- In plants, the first reaction is catalyzed by EC 1.14.15.7, whereas in animals and many bacteria, it is catalyzed by either EC 1.1.99.1 or EC 1.1.3.17. -!- The enzyme involved in the second step, EC 1.2.1.8, appears to be the same in those plants, animals and bacteria that use two separate enzymes.

UniProtKB Entries (1)

Q7X2H8
CHOX_ARTGO
Arthrobacter globiformis
Choline oxidase

PDB Structure

PDB 3LJP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Role of valine 464 in the flavin oxidation reaction catalyzed by choline oxidase.
Finnegan, S., Agniswamy, J., Weber, I.T., Gadda, G.
Biochemistry