CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P14489
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P14489
BLO10_PSEAI
Pseudomonas aeruginosa
Beta-lactamase OXA-10

PDB Structure

PDB 3LCE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cyclobutanone Analogues of beta-Lactams Revisited: Insights into Conformational Requirements for Inhibition of Serine- and Metallo-beta-Lactamases.
Johnson, J.W., Gretes, M., Goodfellow, V.J., Marrone, L., Heynen, M.L., Strynadka, N.C., Dmitrienko, G.I.
J.Am.Chem.Soc.