CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.58.540
Functional Family Botulinum neurotoxin type A

Enzyme Information

3.4.24.69
Bontoxilysin.
based on mapping to UniProt P0DPI1
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.

UniProtKB Entries (1)

P0DPI1
BXA1_CLOBH
Clostridium botulinum A str. Hall
Botulinum neurotoxin type A

PDB Structure

PDB 3K3Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic alpha-Exosite Binding Region.
Dong, J., Thompson, A.A., Fan, Y., Lou, J., Conrad, F., Ho, M., Pires-Alves, M., Wilson, B.A., Stevens, R.C., Marks, J.D.
J.Mol.Biol.