CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family Sialidase A

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt P62576
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P62576
NANA_STRR6
Streptococcus pneumoniae R6
Sialidase A

PDB Structure

PDB 3H73
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of respiratory pathogen neuraminidases
Hsiao, Y.-S., Parker, D., Ratner, A.J., Prince, A., Tong, L.
Biochem.Biophys.Res.Commun.