CATH Classification

Domain Context

CATH Clusters

Superfamily 2.160.20.20
Functional Family

Enzyme Information

3.4.21.72
IgA-specific serine endopeptidase.
based on mapping to UniProt P44969
Cleavage of immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. No small molecule substrates are known.
-!- Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. -!- Some other bacterial endopeptidases with similar specificity are of metallotype (see EC 3.4.24.13). -!- Belongs to peptidase family S6.

UniProtKB Entries (1)

P44969
IGA0_HAEIN
Haemophilus influenzae Rd KW20
Immunoglobulin A1 protease autotransporter

PDB Structure

PDB 3H09
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Active-Site Gating Regulates Substrate Selectivity in a Chymotrypsin-Like Serine Protease The Structure of Haemophilus influenzae Immunoglobulin A1 Protease.
Johnson, T.A., Qiu, J., Plaut, A.G., Holyoak, T.
J.Mol.Biol.