CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family L-threonine 3-dehydrogenase

Enzyme Information

1.1.1.103
L-threonine 3-dehydrogenase.
based on mapping to UniProt Q5JI69
L-threonine + NAD(+) = L-2-amino-3-oxobutanoate + NADH.
-!- Acts in concert with EC 2.3.1.29 in the degradation of threonine to glycine. -!- This threonine-degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex. -!- In aqueous solution, the product L-2-amino-3-oxobutanoate can spontaneously decarboxylate to form aminoacetone.

UniProtKB Entries (1)

Q5JI69
TDH_THEKO
Thermococcus kodakarensis KOD1
L-threonine 3-dehydrogenase

PDB Structure

PDB 3GFB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and function of the l-threonine dehydrogenase (TkTDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis
Bowyer, A., Mikolajek, H., Stuart, J.W., Wood, S.P., Jamil, F., Rashid, N., Akhtar, M., Cooper, J.B.
J.Struct.Biol.