CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Receptor protein serine/threonine kinase

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt Q13873
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q13873
BMPR2_HUMAN
Homo sapiens
Bone morphogenetic protein receptor type-2

PDB Structure

PDB 3G2F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension.
Chaikuad, A., Thangaratnarajah, C., von Delft, F., Bullock, A.N.
Sci Rep