CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Aspartate aminotransferase

Enzyme Information

2.6.1.57
Aromatic-amino-acid transaminase.
based on mapping to UniProt P04693
An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
-!- L-methionine can also act as donor, more slowly. -!- Oxaloacetate can act as acceptor. -!- Controlled proteolysis converts the enzyme to EC 2.6.1.1.
2.6.1.107
Beta-methylphenylalanine transaminase.
based on mapping to UniProt P04693
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3- phenylbutanoate + L-glutamate.
-!- Isolated from the bacterium Streptomyces hygroscopicus NRRL3085. -!- It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin.

UniProtKB Entries (1)

P04693
TYRB_ECOLI
Escherichia coli K-12
Aromatic-amino-acid aminotransferase

PDB Structure

PDB 3FSL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of tyrosine aminotransferase tripple mutant (P181Q,R183G,A321K) from Escherichia coli at 2.35 A resolution
Malashkevich, V.N., Ng, B., Kirsch, J.F.
To be Published