CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Double-stranded RNA-specific adenosine deaminase

Enzyme Information

3.5.4.37
Double-stranded RNA adenine deaminase.
based on mapping to UniProt P55265
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3).
-!- This eukaryotic enzyme is involved in RNA editing. -!- It destabilizes double-stranded RNA through conversion of adenosine to inosine. -!- Inositol hexakisphosphate is required for activity.

UniProtKB Entries (1)

P55265
DSRAD_HUMAN
Homo sapiens
Double-stranded RNA-specific adenosine deaminase

PDB Structure

PDB 3F23
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structures of non-CG-repeat Z-DNAs co-crystallized with the Z-DNA-binding domain, hZ{alpha}ADAR1
Ha, S.C., Choi, J., Hwang, H.Y., Rich, A., Kim, Y.G., Kim, K.K.
Nucleic Acids Res.