CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family glutaminase kidney isoform, mitochondrial

Enzyme Information

3.5.1.2
Glutaminase.
based on mapping to UniProt O94925
L-glutamine + H(2)O = L-glutamate + NH(3).

UniProtKB Entries (1)

O94925
GLSK_HUMAN
Homo sapiens
Glutaminase kidney isoform, mitochondrial

PDB Structure

PDB 3CZD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.
Thangavelu, K., Pan, C.Q., Karlberg, T., Balaji, G., Uttamchandani, M., Suresh, V., Schuler, H., Low, B.C., Sivaraman, J.
Proc.Natl.Acad.Sci.USA