CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC

Enzyme Information

2.1.1.61
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase.
based on mapping to UniProt P77182
S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2- thiouridylate.
-!- Specific for the terminal methyl group of 5-methylaminomethyl-2- thiouridylate.
1.5.-.-
Acting on the CH-NH group of donors.
based on mapping to UniProt P77182

UniProtKB Entries (1)

P77182
MNMC_ECOLI
Escherichia coli K-12
TRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC

PDB Structure

PDB 3AWI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the bifunctional tRNA modification enzyme MnmC from Escherichia coli
Kitamura, A., Sengoku, T., Nishimoto, M., Yokoyama, S., Bessho, Y.
Protein Sci.