CATH Classification

Domain Context

CATH Clusters

Superfamily Acetylglutamate kinase-like
Functional Family Aspartokinase

Enzyme Information

2.7.2.4
Aspartate kinase.
based on mapping to UniProt P26512
ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
-!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 1.1.1.3. -!- This is also the case for two of the four isoenzymes in Arabidopsis thaliana. -!- The equilibrium constant strongly favors the reaction from right to left, i.e. the non-physiological direction of reaction.

UniProtKB Entries (1)

P26512
AK_CORGL
Corynebacterium glutamicum ATCC 13032
Aspartokinase

PDB Structure

PDB 3AB4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism of concerted inhibition of {alpha}2{beta}2-type heterooligomeric aspartate kinase from Corynebacterium glutamicum
Yoshida, A., Tomita, T., Kuzuyama, T., Nishiyama, M.
J.Biol.Chem.