CATH Classification

Domain Context

CATH Clusters

Superfamily Endonuclease/exonuclease/phosphatase
Functional Family 72 kDa inositol polyphosphate 5-phosphatase

Enzyme Information

3.1.3.36
Phosphoinositide 5-phosphatase.
based on mapping to UniProt Q9NRR6
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 4-phosphate + phosphate.
-!- These enzymes can also remove the 5-phosphate from Ins(1,4,5)P(3) and/or Ins(1,3,4,5)P(4). -!- They are a diverse family of enzymes, with differing abilities to catalyze two or more of the four reactions listed. -!- They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. -!- All of them can use either or both of PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) as substrates; this is the main property that distinguishes them from EC 3.1.3.56.

UniProtKB Entries (1)

Q9NRR6
INP5E_HUMAN
Homo sapiens
72 kDa inositol polyphosphate 5-phosphatase

PDB Structure

PDB 2XSW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Inpp5E
Tresaugues, L., Schutz, P., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Siponen, M.I., Thorsell, A.G., Van Der Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Nordlund, P.
To be Published