CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Glyoxylate reductase/hydroxypyruvate reductase b

Enzyme Information

1.1.1.79
Glyoxylate reductase (NADP(+)).
based on mapping to UniProt Q9UBQ7
Glycolate + NADP(+) = glyoxylate + NADPH.
-!- Also reduces hydroxypyruvate to glycerate. -!- Has some affinity for NAD(+).
1.1.1.81
Hydroxypyruvate reductase.
based on mapping to UniProt Q9UBQ7
D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H.

UniProtKB Entries (1)

Q9UBQ7
GRHPR_HUMAN
Homo sapiens
Glyoxylate reductase/hydroxypyruvate reductase

PDB Structure

PDB 2WWR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of Substrate Specificity in Human Glyoxylate Reductase/Hydroxypyruvate Reductase.
Booth, M.P., Conners, R., Rumsby, G., Brady, R.L.
J.Mol.Biol.