CATH Classification

Domain Context

CATH Clusters

Superfamily 2.60.200.20
Functional Family bifunctional polynucleotide phosphatase/kinase

Enzyme Information

3.1.3.32
Polynucleotide 3'-phosphatase.
based on mapping to UniProt Q96T60
A 3'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.
-!- Also hydrolyzes nucleoside 2'-, 3'- and 5'-monophosphates, but only 2'- and 3'-phosphopolynucleotides.
2.7.1.78
Polynucleotide 5'-hydroxyl-kinase.
based on mapping to UniProt Q96T60
ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.
-!- Also acts on 5'-dephospho-RNA 3'-mononucleotides.

UniProtKB Entries (1)

Q96T60
PNKP_HUMAN
Homo sapiens
Bifunctional polynucleotide phosphatase/kinase

PDB Structure

PDB 2W3O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk.
Ali, A.A.E., Jukes, R.M., Pearl, L.H., Oliver, A.W.
Nucleic Acids Res.